![]() J Exp Med 174:1371–1383ĭash P, McClaren JL, Oguin TH 3rd et al (2011) Paired analysis of TCRα and TCRβ chains at the single-cell level in mice. Cell 69:529–537Ĭasanova JL, Romero P, Widmann C, Kourilsky P, Maryanski JL (1991) T cell receptor genes in a series of class I major histocompatibility complex-restricted cytotoxic T lymphocyte clones specific for a Plasmodium berghei nonapeptide: implications for T cell allelic exclusion and antigen-specific repertoire. Nat Rev Immunol 5:772–782īorgulya P, Kishi H, Uematsu Y, von Boehmer H (1992) Exclusion and inclusion of α and β T cell receptor alleles. Hogquist KA, Baldwin TA, Jameson SC (2005) Central tolerance: learning self-control in the thymus. Hamrouni A, Aublin A, Guillaume P, Maryanski JL (2003) T cell receptor gene rearrangement lineage analysis reveals clues for the origin of highly restricted antigen-specific repertoires. Pénit C, Lucas B, Vasseur F (1995) Cell expansion and growth arrest phases during the transition from precursor (CD4-8-) to immature (CD4+8+) thymocytes in normal and genetically modified mice. Sleckman BP, Bassing CH, Hughes MM, Okada A, D’Auteuil M, Wehrly TD, Woodman BB, Davidson L, Chen J, Alt FW (2000) Mechanisms that direct ordered assembly of T cell receptor beta locus V, D, and J gene segments. McBlane JF, van Gent DC, Ramsden DA, Romeo C, Cuomo CA, Gellert M, Oettinger MA (1995) Cleavage at a V(D)J recombination signal requires only RAG1 and RAG2 proteins and occurs in two steps. Immunity 18:65–74Īlt FW, Yancopoulos GD, Blackwell TK, Wood C, Thomas E, Boss M, Coffman R, Rosenberg N, Tonegawa S, Baltimore D (1984) Ordered rearrangement of immunoglobulin heavy chain variable region segments. Jung D, Bassing CH, Fugmann SD, Cheng H-L, Schatz DG, Alt FW (2003) Extrachromosomal recombination substrates recapitulate beyond 12/23 restricted VDJ recombination in nonlymphoid cells. Nature 380:85īassing CH, Alt FW, Hughes MM, D’Auteuil M, Wehrly TD, Woodman BB, Gärtner F, White JM, Davidson L, Sleckman BP (2000) Recombination signal sequences restrict chromosomal V(D)J recombination beyond the 12/23 rule. Nature 290:562–565Įastman QM, Leu TMJ, Schatz DG (1996) Initiation of V (D) J recombination in vitro obeying the 12/23 rule. Sakano H, Kurosawa Y, Weigert M, Tonegawa S (1981) Identification and nucleotide sequence of a diversity DNA segment (D) of immunoglobulin heavy-chain genes. Matthews AGW, Kuo AJ, Ramón-Maiques S et al (2007) RAG2 PHD finger couples histone H3 lysine 4 trimethylation with V(D)J recombination. Teng G, Maman Y, Resch W et al (2015) RAG represents a widespread threat to the lymphocyte genome. Ji Y, Resch W, Corbett E, Yamane A, Casellas R, Schatz DG (2010) The in vivo pattern of binding of RAG1 and RAG2 to antigen receptor loci. Steen SB, Gomelsky L, Speidel SL, Roth DB (1997) Initiation of V (D) J recombination in vivo: role of recombination signal sequences in formation of single and paired double-strand breaks. Nature 547:89–93Ĭabaniols JP, Fazilleau N, Casrouge A, Kourilsky P, Kanellopoulos JM (2001) Most alpha/beta T cell receptor diversity is due to terminal deoxynucleotidyl transferase. Nature 248:701–702ĭash P, Fiore-Gartland AJ, Hertz T et al (2017) Quantifiable predictive features define epitope-specific T cell receptor repertoires. Zinkernagel RM, Doherty PC (1974) Restriction of in vitro T cell-mediated cytotoxicity in lymphocytic choriomeningitis within a syngeneic or semiallogeneic system. The utility of this distinction in research and diagnostic settings is also discussed. Here, we review the case for functional associations with public and private repertoires, their mechanisms of generation, and the implications for future studies of the T cell repertoire. Associations between public and private responses and multiple T cell parameters, including immune efficacy, pathogenicity, and magnitude, have been explored in many experimental systems. One prominent hypothesis to address this phenomenon is convergent recombination, with public receptors being easier to generate through multiple recombination mechanisms. Given the vast potential diversity of the naïve repertoire, this apparently high level of degeneracy suggests one or more non-random mechanisms shaping receptor recombination and selection. These and other data have demonstrated a surprisingly high degree of shared or “public” TCRs at paired and single chain levels found in multiple individuals. ![]() The emergence of next-generation sequencing (NGS)-generated T cell receptor repertoire data has allowed an in-depth look at the diversity of receptor sequences with a previously unobtainable resolution. ![]()
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